New Detection Cartridges Expand Modular Platform Applications

Four new cartridges for a bioresearch detection platform increase the total number of interchangeable choices to 14, extending platform utility for users of the multimode reader.

The new options for Beckman Coulter's (Fullerton, CA, USA) Paradigm Detection Platform include two additional luminescence detection cartridges optimized for 96- and 384-well plate formats, a new detection cartridge for BRET2 (Bioluminescence Resonance Energy Transfer) live cell assays, and a Rhodamine fluorescence cartridge for a selection of cyanine dyes.


Two of the four new detection cartridges expand the platform's Glow Luminescence line with options designed for 96- and 384-well applications, complementing the existing Glow Luminescence Detection Cartridge optimized for the 1536-well plate format. The well-isolating design of each cartridge is optimized for a specific plate format to provide increased sensitivity with reduced cross talk.

Ideal for the study of protein-protein interactions, the Dual Luminescence Detection Cartridge is optimized for use with BRET2 live cell assays and includes predefined protocols and data analysis tools.

The Fluorescence Intensity Detection Cartridge delivers speed and high sensitivity in applications using Cy3 and equivalent Rhodamine fluorescent labels. This new cartridge expands Beckman Coulter's detection menu for FRET (Fluorescence Resonance Energy Transfer) assays by reading Cy3 paired with Cy5 or Cy5.5 dyes, which are commonly used in genomics and proteomics research.

"The Paradigm platform has been very well-received since its introduction last year and customers value its modularity," explained Alisa Jackson, product manager for Beckman Coulter. "With these new cartridges and others that were previously added, we've almost doubled the detection choices since introduction. We will continue to add cartridges for relevant applications."

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