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Pathology

Image: Micrograph of ALL cells. Relapse of the disease following chemotherapy was found to be due to mutations in minor subclones (Photo courtesy of St. Jude Children\'s Research Hospital).

Mutations in Minor Subclones Lead to Leukemia Relapse After Chemotherapy

Cancer researchers monitored changes in the genomic composition of acute lymphoblastic leukemia cells in all stages of cancer progression in order to determine why some cells survived chemotherapy to proliferate and eventually cause the death of the patient.  More...
30 Mar 2015
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Advanced Screening Test Improves Colorectal Cancer Survival Rates

Fecal immunochemical testing is a more advanced method than the traditional three sample stool test, guaiac-based fecal occult blood tests.   More...
29 Mar 2015
Image: Investigators evaluate results of the AQP1 ELISA, part of a noninvasive method to screen for kidney cancer by measuring the presence of protein biomarkers in the urine (Photo courtesy of the Washington University School of Medicine).

Urinary Proteins Kidney Cancer Biomarkers

Two urinary proteins are elevated in individuals with kidney cancer or papillary renal cell carcinoma, and are candidates to serve as biomarkers for early detection of the disease.  More...
29 Mar 2015
Image: Fine needle aspiration cytology of a thyroid nodule showing benign epithelial cells, colloid, and occasional macrophages, typical of a colloid nodule (Photo courtesy of Shahidul Islam, MD, PhD).

Benign Thyroid Nodules Follow-Up Shows Favorable Prognosis

A majority of asymptomatic, benign thyroid nodules exhibited no significant change in size, after five years of follow-up, or actually decreased in size, and diagnoses of thyroid cancer were rare.    More...
24 Mar 2015
Image: Histopathology of cerebral diffuse beta amyloid plaque (Photo courtesy of Dr. Dimitri P. Agamanolis, MD).

Blood-Based Test Developed for Diagnosing Alzheimer's Disease

A simple blood test has been developed to confirm the presence of beta amyloid proteins in the brain, which is a hallmark of Alzheimer's disease, and could be a key advance in diagnosing this neurodegenerative disorder.   More...
23 Mar 2015

British Genomic Study Finds Fifteen New Breast Cancer Loci

British genomic and cancer researchers have identified 15 previously unknown loci associated with the risk of developing breast cancer.  More...
22 Mar 2015
Image: The MiSeq desktop sequencer (Photo courtesy of Konrad Förstner).

Healthy-Looking Prostate Cells Mask Cancer-Causing Mutations

Genome-wide DNA sequencing has been used to decrypt the phylogeny of multiple samples from distinct areas of cancer and morphologically normal tissue taken from the prostates of individuals.  More...
18 Mar 2015
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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