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Pathology

Image: The NanoDrop 8000 UV-Vis Spectrophotometer (Photo courtesy of Thermo Scientific).

DNA Alterations Identified Occur Earliest in Lung Cancer Development

Lungs resected for adenocarcinomas often harbor minute discrete foci of cytologically atypical pneumocyte proliferations designated as atypical adenomatous hyperplasia, which may represent an initial step in the progression to adenocarcinoma in situ.  More...
30 Sep 2015
Image: Scanning electron micrograph of human prostate cancer cells (Photo courtesy of University of Sheffield).

Blood Types Correlate with Survival After Prostate Cancer Vaccine

Simple, inexpensive strategies to target treatment to likely responders could substantially improve efficacy while simultaneously reducing health care costs, but identification of reliable biomarkers has proven challenging.   More...
29 Sep 2015
Image: SensiFAST SYBR No-ROX Kit developed for fast, highly reproducible real-time Polymerase Chain Reactions (PCR) (Photo courtesy of Bioline).

Micro Ribonucleic Nucleic Acid Panel Assays Launched

A novel approach has been developed by combinations of micro ribonucleic nucleic acid specific reverse transcriptase and hemi-nested real-time polymerase chain reaction primers that have been designed to maximize miRNA detection sensitivity and specificity.  More...
28 Sep 2015
Image: Top, breast cancer tumor cells negative for the bone metastasis marker, MFA. Bottom, breast cancer tumor cells positive for the marker (Photo courtesy of Gomis Laboratory, Institute for Research in Biomedicine, Barcelona).

Newly Identified Biomarker Indicates Risk of Breast Cancer Bone Metastasis

Cancer researchers have identified a gene that is critically linked to the ability of some breast cancer tumors to metastasize to the bone and which may be developed into a biomarker to identify patients at risk for this development.  More...
28 Sep 2015
Image: Cancerous cells release small packages of exosomal ribonucleic acid (Photo courtesy of US National Institute of Health).

Liquid Biopsy Test Detects Non-Small-Cell Lung Cancer

Plasma-based assays overcome key challenges associated with tissue-based approaches, enabling sensitive, accurate, real-time mutation detection in non-small-cell lung cancer patients.  More...
23 Sep 2015
Image: Model of the p27KIP1 (cyclin-dependent kinase inhibitor 1B) protein (Photo courtesy of Wikimedia Commons).

Keratin 17 Oncoprotein Potential Cervical Cancer Biomarker

The keratin protein K17, which was thought to play a purely passive mechanical support role for tumors, has been shown to act as a cancer-promoting oncoprotein whose expression by cervical cancer cells is linked to decreased likelihood of survival.   More...
21 Sep 2015
Image: Histopathology of a testicular seminoma with classical histologic features including a prominent lymphoid stromal infiltrate and typical cytomorphology (Photo courtesy of Mattopaedia).

Testicular Cancer Risk Comes from Inherited Genetic Faults

Testing for a range of genetic variants linked to testicular cancer could be effective in picking out patients who are at substantially increased risk, and therefore, potentially opening up ways of preventing the disease.  More...
20 Sep 2015
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.