Pathology

$Image: A diagram of the human prostate gland, roughly the size and shape of a walnut, bisected by the urethra. The locations of each of an individual\'s 13 biopsy cores are indicated. Information obtained via single-cell sequencing from cells sampled from each core indicates the likely location of a cancerous tumor (dotted lines encompassing cores 2, 3 and 6) (Photo courtesy of Cold Spring Harbor Laboratory).$

Single Cell Genomics Utilized for Evaluation of Prostate Cancer

A distinction between indolent and aggressive disease is a major challenge in diagnostics of prostate cancer. Histopathology of tissue biopsies is a standard method used for evaluating cancer risk. Many decades of experience have led to classification of the histological types correlated with clinical outcome. More...
13 Dec 2017

Image: A colored scanning electron micrograph (SEM) of the periodontal pathogen Porphyromonas gingivalis (Photo courtesy of the Forsyth Institute).

Oral Microbiome Composition Reflects Risk for Esophageal Cancers

Esophageal cancer is the eighth most common cancer and the sixth leading cause of cancer death worldwide. Because the disease is often not discovered until it has reached an advanced stage, five-year survival rates range from about 15% to 25% worldwide. More...
12 Dec 2017

Prion Protein Found in Skin of CJD Patients

Creutzfeldt-Jakob disease (CJD) is an incurable, and ultimately fatal, transmissible, neurodegenerative disorder in the family of prion diseases. Prion diseases originate when normally harmless prion protein molecules become abnormal and gather in clusters and filaments in the human body and brain. More...
07 Dec 2017

$Image: A confocal fluorescent microscopy of living nasospheroids developed from a cystic fibrosis patient\'s nasal tissue (Photo courtesy of the University of North Carolina).$

Simple Test Helps CF Patients Find Best Treatment

Individuals with cystic fibrosis (CF) suffer from abnormal secretions in multiple tissues, including the lungs, pancreas, liver, and intestine, leading to mucus stasis and obstruction. Several cutting-edge treatments have become available in recent years to correct the debilitating chronic lung congestion associated with CF. More...
06 Dec 2017

$Image: A histological section showing a obstructed extrahepatic bile duct. It exhibits residual expression of the enzyme called MMP-7 (shown in brown) (Photo courtesy of Cincinnati Children\'s Hospital Medical Center).$