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Pathology

Image: A histopathology of esophageal squamous cell carcinoma with keratin pearl formation (Photo courtesy of Dr. Dharam Ramnani, MD).

Esophageal Cancer GWAS Leads to Risk Variants

Genome-wide association studies have identified common variants associated with risk of esophageal squamous cell carcinoma; however, these common variants cannot explain all heritability of esophageal cancer. More...
15 Feb 2018
Image: Human papilloma virus (HPV) encased in biofilms inside tonsil crypts (pictured) may explain why the roughly 5% of HPV-infected people who develop cancer of the mouth or throat are not protected by their immune systems. Tonsil crypts with HPV are shown in green; epithelial and biofilm layers are shown in red (Photo courtesy of Dr. Katherine Rieth, MD).

HPV Found Hidden on Surface of Tonsils

Human papilloma virus (HPV), the culprit behind cervical cancer and some forms of head and neck cancer may hide in small pockets on the surface of tonsils in people not known to carry the virus. More...
14 Feb 2018
Image: Depiction of circulating tumor cells detaching from a primary tumor and circulating through the bloodstream (Photo courtesy of CellMax Life).

CTC Blood Test Detects Early Stage Colorectal Cancer

Colorectal cancer is among the most preventable cancers when detected early. Yet, it is the second leading cancer killer in the USA. Traditional methods like colonoscopies and stool-based tests are invasive or inconvenient and compliance with colorectal cancer screening remains low, leading to most colorectal cancers being detected in late stages, when survival rates are poor. More...
13 Feb 2018
Image: Diagram of how bacteria play a critical role in the development of colon cancer (Photo courtesy of Elizabeth Cook).

Bacteria Play Critical Role in Driving Colon Cancers

Patients with an inherited form of colon cancer harbor two bacterial species that collaborate to encourage development of the disease, and the same species have been found in people who develop a sporadic form of colon cancer. More...
12 Feb 2018
Image: The LSM 710 confocal microscope (Photo courtesy of Carl Zeiss).

Glycan-Attaching Enzyme Defines Colon Cancer

An enzyme that is absent in healthy colon tissue but abundant in colon cancer cells and this enzyme appears to drive the conversion of normal colon tissue into cancer by attaching sugar molecules, or glycans, to certain proteins in the cell. More...
08 Feb 2018
Image: Histopathology of Endometriosis of the Fallopian Tube (Luminal Pattern). In this pattern, the normal complex, folded tubal mucosa is replaced by flat columnar epithelium with a tin underpinning of specialized endometrial stroma. There are also blood cells in the lumen Photo courtesy of Dr. Ed Uthman).

Genetic Biomarkers Determine Risk of Developing Endometriosis

Endometriosis is one of the most common women's health disorders, causing up to 10% of reproductive-age women to experience painful periods and potential infertility. Diagnosis can elude patients for decades, in part because exploratory surgery is considered the ultimate diagnostic method. More...
07 Feb 2018
Image: (A) Histology of a case of olfactory neuroblastoma with upregulation of CD24 gene by microarray, (B) confirmed by CD24 protein overexpression in the tumor cells (Photo courtesy of Caris Life Sciences).

Analysis Offers Treatment Options for Olfactory Neuroblastoma

Olfactory neuroblastoma (ONB) is a rare, locally aggressive, malignant neoplasm originating in the olfactory epithelium in the nasal vault. The recurrence rate of ONB remains high and there are no specific treatment guidelines for recurrent/metastatic ONBs. More...
01 Feb 2018
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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