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Pathology

Image: A diagram of the hypothesis for the onset mechanism of childhood steroid-sensitive nephrotic syndrome (Photo courtesy of Kobe University).

Susceptible Genes Identified for Childhood Kidney Disease

Childhood nephrotic syndrome, also known as nephrosis, is an incurable disease with an unknown cause, characterized by large amounts of protein leaving the body in the patient's urine, and protein levels in the bloodstream becoming extremely low. More...
09 Aug 2018
Image: A histopathology of adenoid cystic/basal cell carcinoma of the prostate gland (Photo courtesy of Nephron).

Genetic Alterations Correlated to Aggressive Prostate Cancer

Prostate cancer is the second most common cancer among men, and while the disease is often indolent and treatable, some cases are aggressive. Distinguishing between the two could guide treatment decisions. More...
03 Aug 2018
Image: A photomicrograph of pigmented malignant melanoma in a Papanicolaou stained cytology specimen, (Photo courtesy of Nephron).

Melanoma Biomarkers Predict Checkpoint Blocker Response

The outlook for patients with advanced melanoma has dramatically improved in recent years because of drugs known as immune checkpoint inhibitors, which mobilize the immune system to attack cancer. These drugs block checkpoint molecules that act as brakes on the immune system and unleash immune defenders such as T cells to recognize and attack cancer. More...
02 Aug 2018
Image: The Sensiscript reverse transcription kit is ideally suited for highly sensitive applications using very small amounts of RNA (Photo courtesy of Qiagen).

New Target Protein for Colon Cancer Identified

Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the third leading cause of cancer-related death in men and women in the USA. Pathogenic mediators that regulate CRC tumorigenesis are desirable biomarkers to predict prognosis, recurrence of the disease, and response to therapy to improve the management of patients with CRC. More...
02 Aug 2018
Image: A malignant melanoma of the skin (Photo courtesy of National Cancer Institute).

Biomarker Detects Active Melanoma and Predicts Survival

Melanoma is the most dangerous form of skin cancer, these cancerous growths develop when unrepaired DNA damage to skin cells, which is most often caused by ultraviolet radiation from sunshine or tanning beds, triggers mutations (genetic defects) that lead the skin cells to multiply rapidly and form malignant tumors. More...
25 Jul 2018
Image: An immunohistochemistry staining for expression of the estrogen receptor positivity (ER+) showing strong nuclear reactivity (Photo courtesy of the Indian National Institute of Pathology).

Cancer Genetics Highlight Mutations Linked to Drug Response

A range of somatic driver alterations has been described in estrogen receptor–positive, HER2-negative (ER+/HER2−) early breast cancer (BC); however, the clinical relevance is unknown. More...
19 Jul 2018
Image: A histopathology of mixed germ cell tumor of the testes demonstrating the high-grade cytology, typical for embryonal carcinoma (Photo courtesy of Nephron).

Integrated Analyses Offer Molecular Insights to Tumor Subtypes

The most common malignancy of young adult males of European descent are testicular germ cell tumors (TGCTs) of the type derived from germ cell neoplasia in situ (GCNIS). There are two major histologic types: pure classic seminoma and nonseminomatous germ cell tumors (NSGCTs). More...
19 Jul 2018
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.