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Pathology

Image: A histopathology of castration-resistant prostate cancer (Photo courtesy of Andrew J. Armstrong, MD, ScM).

Genomic Data Affects Prognosis of Advanced Prostate Cancer

Heterogeneity in the genomic landscape of metastatic prostate cancer has become apparent through several comprehensive profiling efforts, but little is known about the impact of this heterogeneity on clinical outcome. More...
22 May 2019
Image: The Affymetrix Genechip 7G scanner analyzes next-generation higher-density arrays (Photo courtesy of Thermo Fisher Scientific).

Assay Stratifies Esophageal Cancer Patients for Treatment

The incidence of esophageal adenocarcinoma (OAC) in the Western world has risen six-fold in the last 40 years with the highest incidence occurring in the UK and there were about 9,200 cases of the disease reported in the UK in 2015. It accounts for 3% of cancer cases in the UK each year. More...
22 May 2019
Image: A micrograph of a high-grade serous ovarian carcinoma (Photo courtesy of Wikimedia Commons).

Protein Panel Accurately Differentiates Forms of Ovarian Tumors

A panel of eight proteins was found that distinguishes between the milder endometrioid (EC) and more deadly high-grade serous (HGSC) forms of ovarian cancer with 99.2% accuracy. More...
20 May 2019
Image: (A) Low magnification view of cancer nodule with the central tumor bulk consisting predominantly of invasive cribriform Gleason pattern four. (B) Low magnification view of the same cancer nodule with an outer rim of accentuated syntaphilin (SNPH) staining. The invasive front is defined as the external rim of each cancer nodule abutting the adjacent stroma as outlined in this image as the zone between the dotted and solid lines. Arrows denote accentuated SNPH staining at the tumor-stromal interface (Photo courtesy of the American Journal of Pathology).

Prostate Cancer Severity Indicated by Location and Concentration of Syntaphilin

A biomarker has been identified that may enable doctors to predict which patients with early indications of prostate cancer will be likely to develop the much more serious invasive and metastatic form of the disease. More...
20 May 2019

Clinical Validation Bolsters Liquid Biopsy Evidence Base

Non–small-cell lung cancer (NSCLC) accounts for more than 85% of lung cancer – the majority of patients who present have advanced-stage disease and are treated with systemic therapies. More...
15 May 2019
Image: EndoPredict is a second-generation breast cancer recurrence test for highly accurate assessment of 10-year risk of distant recurrence (Photo courtesy of Myriad Genetics).

Breast Cancer Test Determines Most Effective Treatment

For the clinical management of patients with estrogen receptor (ER)-positive breast cancer, several clinico-pathological and molecular characteristics of the tumor have to be considered for prognosis and treatment decisions. More...
14 May 2019
Image: A photomicrograph showing tumor-infiltrating lymphocytes in a case of colorectal cancer with evidence of high microsatellite instability (MSI-H) on immunostaining (Photo courtesy of Nephron).

Biomarker Predicts Appropriate Immunotherapy for Cancer Patients

Microsatellite instability (MSI) is a hypermutable phenotype caused by the loss of DNA mismatch repair activity. MSI is detected in about 15% of all colorectal cancers; 3% are of these are associated with Lynch syndrome. MSI is a biomarker for response to immune checkpoint inhibitors (ICPIs). More...
14 May 2019
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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