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Pathology

Image: Histopathology of pancreatoblastoma showing a large squamoid nest surrounded by sheet of bland monomorphic cells. Many of the squamous cell nuclei are optically clear due to accumulation of biotin (Photo courtesy of Dharam Ramnani, MD).

Pediatric Pancreatic Cancer Diagnosed From cfDNA Fragments in Urine

Although rare, pancreatoblastoma is the most common pancreatic tumor of young children. Carcinoma of acinar cell origin has rarely been reported in older children. Ductal adenocarcinoma and its many variants are the most common pancreatic tumors in adults, but these are exceedingly rare in children. More...
17 Mar 2021
Image: In-vitro misfolded α-synuclein amplification by real-time quaking-induced conversion (Photo courtesy of University of Edinburgh).

CSF Biomarker Flags Parkinson's Pathology Much Earlier

Isolated rapid-eye-movement (REM) sleep behavior disorder (IRBD) can be part of the prodromal stage of the α-synucleinopathies Parkinson's disease and dementia with Lewy bodies years before clinical symptoms appear. More...
16 Mar 2021
Image: Histopathology of Lewy bodies in the midbrain. A Lewy body in a melanized neuron from the substantia nigra. The Lewy body is the spherical body indicated by an arrow (Photo courtesy of Dr. Susan Daniel).

Five Genes Help Predict Lewy Body Dementia

Lewy body dementia usually affects people over 65 years old. Early signs of the disease include hallucinations, mood swings, and problems with thinking, movements, and sleep. Patients who initially have cognitive and behavioral problems are usually diagnosed as having dementia with Lewy bodies, but are sometimes mistakenly diagnosed with Alzheimer’s disease. More...
10 Mar 2021
Image: Histopathologic image from a patient with Li Fraumeni syndrome showing accumulation of mutant TP53 in tumoral cells (Photo courtesy of Thierry Soussi, PhD).

Clinical Germline Testing Evaluated for Pediatric Cancer Patients

Pediatric cancer is rare, with fewer than 10,000 solid tumors diagnosed in children annually in the USA. Previous studies interrogating germline predisposition broadly across pediatric cancer types have found heritable germline predisposition in 8%–12% of patients. More...
04 Mar 2021
Image: The M220 Focused-ultrasonicator is used for DNA Shearing for Next-Generation Sequencing (Photo courtesy of Covaris).

Genetic Risk of Inflammatory Bowel Disease Appears Distinct in African Americans

The inflammatory bowel diseases Crohn’s disease (CD) and ulcerative colitis (UC) arise in the context of inappropriate activation of the intestinal immune system in response to an environmental trigger in individuals who are genetically predisposed. More...
03 Mar 2021
Image: The QX200 Droplet Digital PCR system (Photo courtesy of Bio-Rad).

ctDNA Provides Prognostic Clues in Advanced BRAF-Mutated Melanoma Cases

A BRAF mutation is a change in a BRAF gene. That change in the gene can lead to an alteration in a protein that regulates cell growth that could allow the melanoma to grow more aggressively. Approximately half of melanomas carry this mutation and are referred to as mutated, or BRAF positive. More...
02 Mar 2021
Image: High-power photomicrograph of ductal adenocarcinoma (Prostate cancer) illustrating tall columnar cells with pale to clear cytoplasm and large ovoid nuclei (Photo courtesy of David J. Grignon, MD).

22-Gene Genomic Classifier Validated in Recurrent Prostate Cancer Patients

When prostate cancer has been detected or has returned following initial treatment with surgery, radiation therapy and/or hormone therapy, it is said to be recurrent or relapsed. Treatment of recurrent prostate cancer depends on what treatment a patient has previously received and the extent of the cancer. More...
25 Feb 2021
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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