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Pathology

Image: The Hyperion Imaging System brings proven CyTOF technology together with imaging capability to empower simultaneous interrogation of four to 37 protein markers using Imaging Mass Cytometry (Photo courtesy of Fluidigm).

Imaging Mass Cytometry Uncovers Novel Breast Cancer Subgroups

Changing the course of how diseases are treated and ultimately cured requires a comprehensive understanding of complex cellular phenotypes and their interrelationships in the spatial context of the tissue microenvironment. More...
03 Feb 2020

$Image: In the brain of mice with Alzheimer\'s, areas near amyloid plaques (A) appear with fewer neural networks (B), dying neurons (C) and higher OCIAD1 (D). In cultured neuronal cells, the OCIAD1 proteins (E) appear in the mitochondria (F) (Photo courtesy of Houston Methodist Research Institute).$

Ovarian Cancer Protein Contributes to Alzheimer`s Disease Neurodegeneration

Alzheimer's disease is a complex neurological disorder with pathological hallmarks of hyperamyloidosis (senile plaques), neurofibrillary tangles containing hyperphosphorylated tau, and extensive neurodegeneration in the brain. More...
30 Jan 2020

Image: The DS-11 Series of Spectrophotometers are used to perform fast quantification of nucleic acids and proteins (Photo courtesy of DeNovix).

Homologous Recombination Defects Prevalent in African-American Cancer Patients

In the USA, African-Americans have the highest cancer incidence and lowest survival across multiple cancer types. The reasons for these persistent trends are not clear. More...
28 Jan 2020

Genome-Wide Association Leads to Heart Failure Risk Loci

Heart failure (HF) affects more than 30 million individuals worldwide and its prevalence is rising. HF-associated morbidity and mortality remain high despite therapeutic advances, with 5-year survival averaging around 50%. More...
23 Jan 2020

Image: Immunostaining of Helicobacter pylori infection in a gastric foveolar pit demonstrated in endoscopic gastric biopsy (Photo courtesy of KGH).

Helicobacter pylori Triggers Development of Stomach Disease

Helicobacter pylori is a paradigm persistent pathogen colonizing about 50% of the human world population and represents a major risk factor for chronic gastritis, peptic ulceration and gastric malignancies. More...
23 Jan 2020

Prostate Cancer Diagnosed Better Using Artificial Intelligence

Prostate cancer is a frequently occurring type of cancer, but not always aggressive: more men die with prostate cancer than from prostate cancer. However, its treatment has many consequences for the quality of life of patients, so determining aggressiveness is an important step in choosing a treatment. More...
22 Jan 2020

Image: Histological immunostaining showing expression of leucine‐rich repeat‐containing G protein–coupled receptor 6 (LGR6) in esophageal squamous cell carcinoma (ESCC) and normal esophageal tissues (NT) (Photo courtesy of Fujian Medical University).

Diagnostic Biomarker Found for Esophageal Squamous Cell Carcinoma

Esophageal cancer is one of the most common malignant tumors in the world, and its incidence ranks seventh among those of all malignant tumors. Esophageal cancer can be divided into two pathological types: squamous cell carcinoma (SCC) and adenocarcinoma. More...
22 Jan 2020

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In Other News

The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.