Pathology
Hyperglycemia Evaluated as a Risk Factor in Pancreatic Cancer
Pancreatic ductal adenocarcinoma (pancreatic cancer) has a five-year survival rate of 9%. Most patients are diagnosed with metastatic disease due to late presenting symptoms and only 10% to 20% are able to undergo surgery with a curative intent. More...23 Jun 2021
Genetic Variants Associated with Unexplained Sudden Cardiac Death
As many as 450,000 Americans die every year from a sudden, fatal heart condition, and in slightly more than one in ten cases the cause remains unexplained even after an autopsy. Most sudden cardiac deaths are caused by abnormal heart rhythms called arrhythmias and the most common life-threatening arrhythmia is ventricular fibrillation. More...22 Jun 2021
CtDNA Analysis Assesses Early Relapse Detection in Colorectal Cancer
Colorectal cancer (CRC) is a type of cancer that begins in the large intestine (colon). The colon is the final part of the digestive tract. Colon cancer typically affects older adults, though it can happen at any age. It usually begins as small, noncancerous (benign) clumps of cells called polyps that form on the inside of the colon. Over time some of these polyps can become colon cancers. More...17 Jun 2021
Liquid Biopsies Detect Pediatric Bone Tumors Based on Epigenetic Profiles
Sequencing of cell-free DNA (cfDNA) in the blood of cancer patients (liquid biopsy) provides attractive opportunities for early diagnosis, assessment of treatment response, and minimally invasive disease monitoring. As a consequence, cfDNA analysis holds great promise for precision oncology and personalized therapies, and is currently evaluated in a broad range of clinical studies. More...17 Jun 2021
Genomic Differences Cause Racial Disparities in Prostate Cancer
Prostate cancer is a disease defined by the abnormal growth of cells. These abnormal cells can proliferate in an uncontrolled way and, if left untreated, form tumors which may metastasize or spread to other parts of the body. Prostate cancer (PCa) is the most common solid organ malignancy in men, with 174,650 new diagnoses and 31,620 deaths expected in 2019 in the USA alone. More...17 Jun 2021
Intraoperative Frozen Section Detect Acute Invasive Fungal Rhinosinusitis
Acute invasive fungal rhinosinusitis (AIFRS) is a potentially lethal and rapidly progressive disease. It primarily affects immunocompromised or diabetic patients, in whom organisms that are ubiquitous, but usually harmless can invade mucosa and rapidly disseminate to the orbit and cranial cavity. More...09 Jun 2021
Analytic Validation and Clinical Utilization of Comprehensive Genomic Profiling Test
Cancer has a high clinical burden and oncology therapies are expensive. It is estimated that 1,898,160 new cancer cases will be diagnosed and over 608,570 deaths are projected to occur in the USA in 2021. The prevalence of cancer is expected to rise over time, providing an expanding unmet need for genomic tests to help physicians treat patients in a more precise manner. More...02 Jun 2021
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In Other News
Colorectal Cancer Relapse Predicted by ctDNA Clearance
Jagged Ends of Urinary Cell-Free DNA Assessed in Bladder Cancer Detection
Jagged Ends of Urinary Cell-Free DNA Assessed in Bladder Cancer Detection
Loss of Function Mutations in GEMIN5 Cause a Neurodevelopmental Disorder
Human Microbiota Flagellins Drive Adaptive Immune Responses in Crohn’s Disease
Rapid, Direct-to-Digital Prostate Biopsy Pathology Evaluated
Developed Immunoassay Predicts Benefits of Anti-PD-1 Therapy in NSCLC
Holographic Histopathology Enables Fast, Precise Diagnostics
Genetic Background and Clinicopathologic Features Established for Adult-Onset Nephronophthisis
African-American MS Patients Experience More Rapid B-Cell Repopulation
GPS Assay Associated with Long-Term Prostate Cancer Outcomes
New Genetic Factors Involved in Sudden Unexpected Death in Children
Altered Perivascular Fibroblast Activity Precedes ALS Disease Onset
RNA-Sequencing Predicts Immunotherapy Success in Bladder Cancer
Tissue Counterpart to Monoclonal B-Cell Lymphocytosis Characterized
Breast Cancer Histopathology Employs Infrared Spectroscopic Imaging
Coagulation Dysfunction and Infection Evaluated in Patients with AECOPD
Spatial Landscape of Lung Pathology Investigated During COVID-19 Progression
Leukocyte Epigenomics and Artificial Intelligence Predict Late-Onset Alzheimer’s Disease
Single-Cell Transcriptomic Analysis Traces Neuroblastomas to Developing Adrenal Neuroblasts
Whole-Genome Sequencing Aids Rare Disease Diagnosis
Calcitonin and Procalcitonin Immunoassays Investigated for Medullary Thyroid Carcinoma
Immune Cells in Cerebrospinal Fluid Predict Response to Immunotherapy
The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.