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Pathology

Image: Testing Neurofilament Light (NF-L) chain in blood samples to monitor neurodegenerative diseases: qualification of an ultrasensitive immuno-assay using clinical serum and plasma samples (Photo courtesy of Advanced BioScience Laboratories, Inc)

Neurofilament Light Biomarker Linked With Parkinson's Disease

Parkinson's disease is caused by a loss of nerve cells in part of the brain called the substantia nigra. This leads to a reduction in a chemical called dopamine in the brain. Blood biomarkers may allow earlier identification of Parkinson’s disease (PD), Parkinsonism, and poor PD-related outcomes, such as physical functioning. More...
19 Apr 2022
Image: Fluidigm CyTOF2 Mass Cytometer (Photo courtesy of University of Minnesota)

Epigenomic Biomarker Predict CAR T-Cell Therapy Resistance in Pediatric Leukemia

Children with acute lymphoblastic leukemia (ALL) whose cells express an epigenomic biomarker rooted in DNA methylation patterns may be less likely to respond to CD19-directed CAR T-cell therapy. More...
18 Apr 2022
Image: Renasight is a test to determine if there is a genetic cause for an individual’s kidney disease or if there is an increased hereditary risk due to family history. The test uses a blood or saliva sample to test 385 genes associated with chronic kidney disease (CKD) (Photo courtesy of Natera)

Broad Gene Panel Diagnoses Patients With Kidney Disease

Chronic kidney disease (CKD) is a major public health issue in the USA. Identification of monogenic causes of CKD, which are present in ∼10% of adult cases, can impact prognosis and patient management. For the ∼800,000 individuals in the USA with end-stage kidney disease (ESKD), genetic diagnosis may inform the selection of potential-related kidney donors, assess the risk of disease recurrence, and guide clinical management following transplant. More...
13 Apr 2022
Image: Digitized pathology slides and associated metadata (Photo courtesy of Pramana, Inc.)

First-of-Its-Kind AI-Enabled Service Digitizes Glass Slides to Help Labs Create Digital Pathology Repositories

Despite the potential value and impact of digitizing pathology archives, few pathology labs have achieved large scale digital libraries. Due to the vastly different slide preparation methods over the years as well as the deterioration of slides in storage, the highly labor-intensive process often results in poor quality and inconsistent images. Now, a vertically integrated solution offers a completely automated means for digitization at scale, enabling significant operational efficiencies by limiting human intervention. More...
25 Mar 2022
Image: Genetic Overlap Found for Ovarian Cancer Subtypes and Endometriosis (Photo courtesy of University of Queensland)

Genetic Overlap Found for Ovarian Cancer Subtypes and Endometriosis (Cell Reports Medicine: University of Queensland)

A research team in Australia, the US, and the UK has delved into genetic ties between specific epithelial ovarian cancer (EOC) histotypes and endometriosis, a condition previously associated with enhanced EOC risk. More...
22 Mar 2022
Image: The Cellometer K2 utilizes brightfield imaging and dual-fluorescence imaging to quickly and accurately identify and count individual cells. Cell count, concentration, diameter, and % viability are automatically calculated and reported (Photo courtesy of Nexcelom Bioscience)

Single Cell Characterization Acral Melanoma Identifies Novel Targets for Immunotherapy

Acral melanoma is a rare subtype that represents roughly 3% of all melanoma cases. Unlike typical melanoma that occurs on sun-exposed skin, acral melanoma develops on the nonhair bearing skin of the soles, palm and nail beds. There is very little information known about the development of acral melanoma. More...
16 Mar 2022
Image: Visualizing the invisible: New fluorescent DNA label reveals nanoscopic cancer features using a custom-built system on the Olympus IX71 Inverted Microscope (Photo courtesy of Fluorescence Microscopes)

New Fluorescent DNA Label Reveals Nanoscopic Cancer Features

Researchers have developed a new fluorescent label that gives a clearer picture of how DNA architecture is disrupted in cancer cells. The findings could improve cancer diagnoses for patients and classification of future cancer risk. More...
15 Mar 2022
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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