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Microbiology

Image: A collection of SHERLOCK paper test strips: Unused paper strips (Left); Paper tests displaying a negative SHERLOCK readout (Middle); Paper tests displaying a positive SHERLOCK readout (Right) (Photo courtesy of Broad Institute of MIT and Harvard).

Diagnostic SHERLOCK Optimized for Rapid Viral Detection

New technique enables SHERLOCK to detect a virus directly in bodily fluids, eliminating a step that required laboratory equipment and expanding the platform's potential to quickly and cheaply track pathogens such as Zika during an outbreak. More...
08 May 2018
Image: A photomicrograph of a brain tissue specimen revealed the presence of hooklets in a case of cysticercosis, an infection due to the ingestion of eggs of a pork tapeworm, Taenia solium (Photo courtesy of the University of Pennsylvania Medical Center).

Metagenomic Sequencing Can Diagnose Cases of Meningitis

Subacute and chronic meningitis are diagnostically challenging given the wide range of potential infectious, autoimmune, neoplastic, paraneoplastic, parameningeal, and toxic causes. Securing a final diagnosis can require weeks or months of testing or remain unsolved, necessitating empirical treatment approaches that may be ineffective or even harmful. More...
01 May 2018
Image: A strain of Candida auris cultured in a petri dish. C. auris is difficult to identify with standard laboratory methods, and can be misidentified in laboratories without specific technology (Photo courtesy of the CDC).

Test Authorized to Identify Candida auris

Candida auris is a yeast that can cause serious infections in hospitalized patients such as bloodstream infections and is frequently resistant to multiple antifungal drugs used to treat Candida infections. The US Administration has authorized the first test to identify the emerging pathogen (C. auris), which can cause serious infections in hospitalized patients. More...
30 Apr 2018
Image: A positive C. DIFF QUIK CHEK COMPLETE. The assay simultaneously tests for GDH and Toxins A & B providing actionable C. difficile results in less than 30 minutes (Photo courtesy of Alere).

Clostridium difficile Examined by Different Methods

The epidemiology of Clostridium difficile infection (CDI) has shifted in the last decade and is now affecting populations previously at low risk to include healthy adults, peripartum women and young children. More...
30 Apr 2018
Image: The Xpert MTB/RIF assay loaded into the GeneXpert 4-module machine (Photo courtesy of Cepheid).

Rapid Diagnostic Test Evaluated for Tuberculosis

The diagnosis of smear-negative and extrapulmonary Tuberculosis (TB) remains challenging in resource-limited settings. Confirmation of smear-negative and extrapulmonary TB cases requires a positive Mycobacterium tuberculosis culture, which may take up to eight weeks. More...
26 Apr 2018
Image: The MAST ISOPLEX DNA kit is a ready to use amplification kit, making molecular diagnostics with LAMP easy and efficient (Photo courtesy of Mast Diagnostica).

Treponemal Subspecies Discriminated by LAMP

Human yaws is a tropical skin disease of children caused by the bacterium Treponema pallidum subsp. pertenue (TPE). Skin ulcers are the most characteristic clinical manifestations associated with infection in all three active disease stages, primary, secondary, and tertiary yaws. More...
26 Apr 2018
Image: The COBAS TaqMan HBV test (Photo courtesy of Roche Diagnostics).

Assay Detects Hepatitis B in Multiple Specimens

Hepatitis B virus (HBV) infection has led to more than 686,000 deaths worldwide per year. Approximately two billion individuals worldwide are infected with HBV and are at risk of developing cirrhosis and hepatocellular carcinoma, which ranks fifth in terms of malignant cancer mortality. More...
25 Apr 2018
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The LabMedica Microbiology channel provides the latest news in the fields of epidemiology, bacteriology, virology, and parasitology, all viewed from the unique perspective of Laboratory Medicine.