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Immunology

Image: nCounter NanoString: Gene expression profiling platform (Photo courtesy of Institute Pasteur).

Gene Expression Signature Traces Nonalcoholic Fatty Liver Disease Progression

Nonalcoholic fatty liver disease (NAFLD) is a common condition marked by the accumulation of triglycerides and other lipids in the liver and is associated with metabolic syndrome, type 2 diabetes, hypertension, and dyslipidemia. More...
16 Dec 2020
Image: The GSP instrument is a high throughput batch analyzer intended for quantitative or qualitative measurement of neonatal screening samples on 96-well microplates (Photo courtesy of PerkinElmer).

Biomarker Evaluated for Early Detection of Congenital Heart Disease

Congenital heart disease (CHD) is the most common congenital malformation in humans worldwide. Circulating cardiovascular biomarkers could potentially improve the early detection of CHD, even in asymptomatic newborns. More...
16 Dec 2020
Image: Rheumatoid arthritis (RA)‐derived neutrophils exhibited increased spontaneous NETosis and increased NETotic response to tumor necrosis factor (TNF)‐α. Neutrophils were isolated from patients with RA and healthy controls (HC) (Photo courtesy of Central South University).

Anti‐Citrullinated Antibodies Associated with NET Formation in Rheumatoid Arthritis

Several cell types can form extracellular traps as a primary immune response when pathogens invade the body or other inflammatory stimuli. These cell types include neutrophils, monocytes, eosinophils, and mast cells. The mechanism by which neutrophil extracellular traps (NETs) are formed is known as NETosis. More...
14 Dec 2020
Image: Triple fecal immunochemical testing (FIT) surpasses single sigmoidoscopy in colorectal cancer (CRC) screening (Photo courtesy of Pinnacle Biolabs).

Triple FIT Surpasses Single Sigmoidoscopy in CRC Screening

Colorectal cancer (CRC) almost always develops from precancerous polyps (abnormal growths) in the colon or rectum. Screening tests can find precancerous polyps, so that they can be removed before they turn into cancer. Screening tests can also find colorectal cancer early, when treatment works best. More...
10 Dec 2020
Image: The Spark 10-M multimode reader performs accurate and sensitive measurements of fluorescent cell-based assays (Photo courtesy of Tecan Group Ltd).

Kininogen-1 Protein Linked to Early Cognitive Impairment in Parkinson’s

Cognitive impairment is a common feature in Parkinson's disease (PD), associated with increased morbidity and mortality. An ongoing area of PD studies is the search for biomarkers that can provide prognostic information about cognitive impairment and other symptoms. More...
03 Dec 2020
Image: The Luminex MAGPIX Instrument System (Photo courtesy of Thermo Fisher Scientific).

Single-Tube Multimarker Assay Estimates Preeclampsia Risk

The challenge in the clinical practice of pregnancy monitoring is to distinguish isolated gestational hypertension or proteinuria from the development of preeclampsia (PE) with potential severe consequences to the mother and unborn child. More...
03 Dec 2020
Image: The Bio-Plex Pro Human Th17 Cytokine Panel enables measurement of analytes in diverse matrices such as serum, plasma, and cell culture supernatants (Photo courtesy of Bio-Rad).

Cytokine Profiles Characterized in Primary Sjögren´s Syndrome Patients

Primary Sjögren's syndrome (pSS) is an autoimmune disease characterized by a lymphocytic infiltrate in salivary glands driving to epithelial damage. The pSS patients present heterogenic clinical and serological characteristics. More...
02 Dec 2020
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.