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Immunology

Image: Blood sample tube for Immunoglobulin G or IgG subclass test (Photo courtesy of Blood Tests London)

Immunoglobulin Levels Investigated in Adults with IgG Subclass Deficiency

Immunoglobulin G (IgG) subclass deficiency (IgGSD) is characterized by frequent or severe upper or lower respiratory tract infection, one or more subnormal IgG subclass level(s) unexplained by other causes, and decreased IgG response to pneumococcal polysaccharide vaccination (PPSV). More...
30 Aug 2021
Image: Histopathology of (a) Usual-type high-grade urothelial carcinoma and (b) Positive E-cadherin expression in usual-type high-grade urothelial carcinoma. (Photo courtesy of Emory University School of Medicine)

Biomarker p-120 Catenin Distinguishes Conventional Urothelial Carcinoma from Variants

Plasmacytoid urothelial carcinoma (PC-UC) is an infrequent and clinically aggressive variant of urothelial carcinoma (UC). Initially, PC-UC was identified based on morphology as a potential mimicker of malignant plasma cell and lymphoid neoplasms and is characterized by loss of E-cadherin (E-Cad)–mediated intercellular adhesion. More...
24 Aug 2021
The LIAISON XL is a fully automated chemiluminescence analyzer, performing complete sample processing as well as measurement and evaluation (Photo courtesy of DiaSorin)

Automated Assays Evaluated For High-Sensitivity Thyroglobulin Measurement

Thyroglobulin (Tg) is a tumor marker for differentiated thyroid carcinoma (DTC) originating from thyroid follicular cell and is an important tumor marker for therapy control. Over the past decade, assays for highly sensitive Tg measurement have become increasingly established. More...
12 Aug 2021
Antisynthetase Syndrome Patients with positive immunohistochemistry reaction of (A) YKL-40, (B) YKL-40 (higher magnification); (C), a specimen from a patient with antisynthetase syndrome, but without infiltrate inflammation; (D) CD68, (E) CD4, and (F) CD8 (Photo courtesy of Universidade de Sao Paulo).

Serum YKL-40 Levels Measured In Antisynthetase Syndrome Patients

Antisynthetase syndrome (ASSD) is a rare systemic autoimmune myopathy characterized by muscle, joint, and pulmonary involvement, as well as by the presence of fever, “mechanic’s hands,” and Raynaud’s phenomenon. More...
10 Aug 2021
A novel protein-based multitarget fecal immunochemical test (mFIT) for colorectal cancer (CRC) screening was superior to conventional FIT in detecting advanced neoplasia, particularly advanced adenomas (Photo courtesy of Mike Bassett)

Multitarget Fecal Immunochemical Test Validated for Colorectal Cancer

Colorectal cancer (CRC) starts in the colon or the rectum. These cancers can also be called colon cancer or rectal cancer, depending on where they start. Colon cancer and rectal cancer are often grouped together because they have many features in common. More...
08 Aug 2021
The Invitrogen Human EGF ELISA Kit measures levels of epidermal growth factor (EGF) in human serum, plasma, and cell culture supernatant using 96-well plates (Photo courtesy of Thermo Fisher Scientific)

Urinary Epidermal Growth Factor Investigated for Diabetes Nephropathy

Type 1 diabetes mellitus is an auto-immune metabolic disease with chronic hyperglycemia. For many patients with type 1 diabetes (T1DM), it is challenging to maintain near-normal glucose blood levels and to reduce the risk of both acute (hypoglycemia, ketoacidosis) and chronic microvascular (retinopathy, neuropathy and nephropathy) and macrovascular complications. More...
06 Aug 2021
Multi-omics reveal microbial determinants impacting responses to biologic therapies in inflammatory bowel disease (Photo courtesy of Massachusetts General Hospital)

Microbiome and Metabolic Features Tied to IBD Treatment Response

Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine. Crohn's disease and ulcerative colitis are the principal types of inflammatory bowel disease. More...
06 Aug 2021
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.