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Immunology

Image: The SpectraMax plus microplate reader was used to show that regulatory T cells in erythema nodosum leprosum maintain anti-inflammatory function (Photo courtesy of Molecular Devices)

Regulatory T Cells in Leprosy Maintain Anti-Inflammatory Function

Leprosy is caused by Mycobacterium leprae, an intracellular acid-fast bacillus and is complicated by episodes of inflammation called leprosy reactions. Leprosy reactions are important causes of nerve damage and illness. More...
10 Aug 2022
Image: Photomicrograph of Treponema pallidum bacterial spirochetes, which exhibited their characteristic corkscrew shape using the dark field visualization technique (Photo courtesy of Louisa Lu, MD)

Recombinant Antigens Assessed for Serological Diagnosis of Syphilis

Syphilis is a chronic multisystemic disease caused by infection with the spirochete Treponema pallidum and acquired usually via sexual exposure or via vertical mother–fetus transmission or by blood transfusions. An estimated 18 million cases worldwide and 5.6 million new cases occur annually. More...
09 Aug 2022
Image: Maternal Fc-mediated non-neutralizing antibody responses correlate with protection against congenital human cytomegalovirus infection (Photo courtesy of Weill Cornell School of Medicine).

Maternal Antibodies Can Protect Infants from Cytomegalovirus

Human cytomegalovirus (HCMV) is the most common congenital infection and a leading cause of stillbirth, neurodevelopmental impairment, and pediatric hearing loss worldwide. Antibodies that summon virus-engulfing white blood cells may play an important role in protecting infants from potentially serious congenital infection with HCMV. More...
26 Jul 2022
Image: The Alinity I Immunoassay analyzer (Photo courtesy of Abbott)

Highly Sensitive Thyroglobulin Chemiluminescent Microparticle Immunoassay Evaluated

Differentiated thyroid cancer (DTC) is the most frequent endocrine malignancy. Standard treatment of DTC is thyroidectomy plus, for high risk cases, radioactive iodine ablation therapy, and pharmacological suppression of TSH. More...
20 Jul 2022
Image: The CyTOF Helios Mass Cytometer simultaneously resolves multiple parameters with minimal signal overlap (Photo courtesy of University of Virginia)

Glycans on CD4+ T Cells Impact HIV Susceptibility

High-parameter single-cell phenotyping has enabled in-depth classification and interrogation of immune cells, but to date has not allowed for glycan characterization. Living cells have a sugar coating. These sugars include molecules called glycans, which help cells, interact with other biological entities. More...
13 Jul 2022
Image: Kallestad Anti-dsDNA EIA, Bio-Rad Autoimmune Anti-dsDNA EIA and Bio-Rad Autoimmune EIA Anti-ssDNA. Anti-DNA testing is intended for use in the diagnosis and management of systemic lupus erythematosus (SLE) and certain other rheumatic diseases (Photo courtesy of Bio-Rad)

Anti-Double Stranded DNA Antibodies Diagnose Systemic Lupus Erythematosus

Anti-double-stranded deoxyribonucleic acid antibodies (anti-dsDNA Abs) embrace antibodies with a wide spectrum of fine molecular specificities that are produced persistently in the context of true autoimmunity or transiently in context of infections or other clinical conditions. More...
13 Jul 2022
Image: The UNI-CAP immunoanalyzer is intended for allergy testing using ImmunoCAP (Photo courtesy of Thermo Fisher Scientific)

Immunobiomarkers in Chronic Rhinosinusitis Correlate with Clinical Severity

Chronic rhinosinusitis comprises a heterogeneous group of inflammatory disorders. It is assumed that the disease process lasts over 12 weeks and is accompanied by two or more symptoms, such as nasal discharge/postnasal drip, nasal congestion, sinus pain/pressure, and anosmia/hyposmia. More...
06 Jul 2022
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.
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