Clinical Chemistry
Vitamin D Deficiency Linked to Metabolic Changes in Lupus Patients
Systemic lupus erythematosus (SLE), is the most common type of lupus. SLE is an autoimmune disease in which the immune system attacks its own tissues, causing widespread inflammation and tissue damage in the affected organs. It can affect the joints, skin, brain, lungs, kidneys, and blood vessels. More...15 Apr 2021
Circulating Calprotectin as Biomarker in Neutrophil-Related Inflammation
Calprotectin (CLP) acts as an endogenous ligand of different cell-surface proteins like Toll-like receptor 4 and receptor of advanced glycation end-products facilitating a local proinflammatory effect. CLP is mostly secreted through an active, calcium-dependent Protein Kinase C (PKC) pathway, next to the passive leakage from necrotic cells and release in neutrophil extracellular traps (NET). More...15 Apr 2021
Coagulation Dysfunction and Infection Evaluated in Patients with AECOPD
Chronic obstructive pulmonary disease (COPD) is one of the common chronic airway obstructive diseases, characterized by persistent respiratory symptoms and airflow limitation. In acute exacerbation stage (AECOPD), patients developed respiratory failure often have circulatory and coagulation dysfunction, which was considered the cause of thrombosis events in the patients. More...14 Apr 2021
Performance of Five Lipoprotein(a) Immunoassays Evaluated
Increased serum Lipoprotein(a) [Lp(a)] is considered an independent, inherited risk factor for atherosclerotic cardiovascular disease (ASCVD), including myocardial infarction and stroke. This risk is believed to be due to pro-atherogenic, pro-inflammatory, and pro-thrombotic properties of the Lp(a) particle More...06 Apr 2021
Flow-Cytometric Expression of Endoglin Assessed in B-Acute Lymphoblastic Leukemia
Acute lymphoblastic leukemia (ALL) is a malignant disorder representing clonal expansion and arrest of maturation of lymphoid progenitor cells in the bone marrow, blood, and extramedullary sites. The incidence of ALL generally follows a bimodal distribution, with its first peak occurring in childhood and the second around the age of 50. More...01 Apr 2021
NMR-Based Method Measures Circulating Blood Citrate Levels
Recent studies show that citrate is involved in several biological processes such as inflammation, cancer, insulin secretion, acetylation of histones, neurological development and hydroxylglutaric aciduria, indicating that it has functions beyond energy regulation. More...31 Mar 2021
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In Other News
Vitamin D Levels Tied to COVID-19 Risk for African-Americans
White Blood Cell Help Define Pediatric Urinary Tract Infections
Calcitonin and Procalcitonin Immunoassays Investigated for Medullary Thyroid Carcinoma
Chemiluminescence Anti‐Müllerian Hormone Assay Performance Characterized
Cardiac Troponins Assessed for Acute Heart Failure
CSF Biomarker Flags Parkinson's Pathology Much Earlier
Blood Biomarker Discovered for Autism Spectrum Disorder
Biomarker Protein Investigated in Juvenile Idiopathic Arthritis
Immune Response to Insulin Identifies Risk of Juvenile-Diabetes
Fibrinogen to Albumin Ratio Reflects ANCA‐Associated Vasculitis Activity
Three Automated Urine Analyzers Compared with Manual Microscopic Urinalysis
Stabilized Urinary Biogenic Amines Measured in Clinical Chemistry Laboratories
Biomarkers Evaluate Kidney Injury in Cancer Patients
Blood Test Distinguishes Epileptic Seizures From PNES
Abnormal Liver Function Test Associated with Severe SARS-CoV-2 Infection
New Control Mechanism Discovered in Innate Immune System
Reference Intervals for Liver Function Tests Established for Minors
Automated Urine Microscope Verified for Regional Laboratories
UPLC-MS/MS Method Simultaneously Determines Plasma Catecholamines and Their Metabolites
Tryptophan Metabolism Is Dysregulated in Individuals with Fanconi Anemia
Serum Pentosidine Levels Measured in Systemic Lupus Erythematosus
Angiopoietin-Like 2 Is a Biomarker for Diabetic Foot Patients
Gestational Lipid Profiles Associated with Adverse Cardiovascular Risk
The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.