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Clinical Chemistry

Blood Metabolites May Serve as Kidney Function Indicators

A nontargeted metabolomics approach in which gas and liquid chromatography were coupled to mass spectrometry was used to quantify 493 small molecules in human serum and relate them to changes in kidney function due to chronic kidney disease.  More...
19 Oct 2015
Image: Histopathology of an adrenal incidentaloma showing the pushing border between the adenoma and the surrounding parenchyma (arrows) (Photo courtesy of the Government of Western Australia).

Novel Urinary Biomarkers May Indicate Adrenal Cancer

A global analysis of metabolites and small molecules in urine samples from patients with adrenal cancer has identified four biochemicals that, when measured together, can distinguish malignant from benign adrenal tumors.   More...
19 Oct 2015
Image: The Afinion C-reactive protein (CRP) Test Cartridge contains all reagents necessary for measurement of CRP in whole blood, serum or plasma (Photo courtesy of Alere).

Quick Test Minimizes Unnecessary Primary Care Antibiotic Prescribing

C-reactive protein is a biomarker in blood which indicates the presence of inflammation, and the amount of CRP in the body gives an indication of the severity of an infection. Low levels of CRP are indicative of viral or self-limiting bacterial infections, and high levels indicate serious infection.   More...
19 Oct 2015
Image: Schematic representation of analysis of breath samples for the diagnosis of ovarian cancer (Photo courtesy of Technion).

Compounds Detected in Breath Samples Specific to Ovarian Cancer

Diagnosing cancer today usually involves various imaging techniques, examining tissue samples under a microscope, or testing cells for proteins or genetic material.   More...
13 Oct 2015
Image: Schematic representation of DNA-based electrochemical sensor (Photo courtesy of University of Montreal).

Rapid, Simple, Inexpensive Diagnostic Tests Developed Using DNA

A highly selective DNA-based electrochemical sensor that utilizes steric hindrance effects to signal the presence of large macromolecules in a single-step procedure has been developed.  More...
12 Oct 2015
Image: The two key lab in a chip components with a syringe for scale, which will allow for rapid liver toxicity tests (Photo courtesy of Nanyang Technological University).

Real-Time Mobile Laboratory Developed for Needle Device

A truly practical lab-on-a-chip system for point-of-care testing hepatotoxicity assessment necessitates the embodiment of full-automation, ease-of-use and “sample-in-answer-out” diagnostic capabilities.  More...
12 Oct 2015
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New Automated Chemistry Analyzer Presented at IBMS 2015

A new clinical chemistry analyzer provides an automated bench-top platform with an integrated chemistry system supported by a broad menu of ready-to-use, bar coded reagents.  More...
11 Oct 2015
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.