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Clinical Chemistry

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Prediabetes Linked to Early Kidney Damage

The role of prediabetes as a risk factor for hyperfiltration and albuminuria in persons who do not develop diabetes is unclear and the lack of evidence is mainly due to the difficulty of accurately assessing the glomerular filtration rate in the near-normal range of GFR.   More...
10 Jan 2016
Image: Immunohistochemistry of an estrogen receptor-positive breast cancer surgical pathology specimen; most of the cancer cell nuclei stain strongly positive (dark brown) for estrogen receptor (ER) (Photo courtesy of Dr. Ronald S. Weinstein, MD).

Commercial Assay Aids Physicians in Tamoxifen Drug Monitoring

A laboratory developed test could help assess levels of several tamoxifen drug metabolites in a blood specimen which is important as five years of therapy with tamoxifen has been the standard of care for women with early stage, estrogen-receptor-positive breast cancer following "curative" surgery.   More...
30 Dec 2015
Image: The glomerular filtration rate calculator used to estimate chronic kidney disease (Photo courtesy of The National Institute of Diabetes and Digestive and Kidney Diseases).

Simple Test of Kidney Function Needs More Consideration

Kidney disease in the USA and other parts of the world is both common and under-diagnosed, but new studies suggest that paying close attention to results of a simple blood test can help predict the likelihood that patients will develop kidney failure.   More...
29 Dec 2015
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New Method Diagnoses Deadly Fungal Lung Infection

A new way has been discovered for the early detection of a potentially deadly fungal infection in patients with suppressed immune systems such as those being treated for leukemia or have had an organ transplant.    More...
29 Dec 2015
Image: Micrograph from a prostate biopsy showing a prostatic adenocarcinoma, conventional (acinar) type, the most common form of prostate cancer (Photo courtesy of Nephron).

Prostate Cancer Screening Improved by Repeating Abnormal Tests

For more than 20 years, the prostate-specific antigen test has been used to help screen for prostate cancer, but in recent years, some task forces have called for this blood test to be abandoned because it leads to many unnecessary biopsies.  More...
29 Dec 2015
Image: Automated Chemiluminescence System (ACS)-180 analyzer (Photo courtesy of Bayer).

Elevated Sex Hormone Levels Raise Risk of Uterine Fibroids

Women who have high levels of both testosterone and estrogen in midlife may face a greater risk of developing benign tumors on the uterus called uterine fibroids than women with low levels of the hormones.   More...
28 Dec 2015

New Assays to Measure Immunosuppressive Drugs Now Available

Two new clinical autoanalyzer tests for measurement of immunosuppressive drugs have been released to the market.  More...
27 Dec 2015
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.