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Clinical Chemistry

Image: The relationship between delay in initial lactate measurement and the probability of in-hospital mortality for patients meeting SEP-1 criteria, stratified by level of initial lactate value (mmol/L) and adjusted for patient location, eCART score, and lactate value (Photo courtesy of University of Chicago).

Earlier Measurements Offer Quicker Treatment for Sepsis

Sepsis remains a significant cause of morbidity and mortality in the USA, leading to the implementation of the Severe Sepsis and Septic Shock Early Management Bundle (SEP-1). SEP-1 identifies patients with “severe sepsis” via clinical and laboratory criteria and mandates interventions, including lactate draws and antibiotics, within a specific time window. More...
07 Jun 2018
Image: A pregnant woman with a stethoscope placed to her stomach. Scientists have developed a test to predict a woman\'s risk of preterm birth (Photo courtesy of University of California - San Francisco).

New Test Predicts Risk of Preterm Birth

A test has been developed to predict a woman's risk of preterm birth when she is between 15 and 20 weeks pregnant, which may enable doctors to treat them early and prevent severe complications later in the pregnancy. More...
06 Jun 2018
Image: The Access 2 benchtop immunoassay system (Photo courtesy of Beckman Coulter Diagnostics).

Vitamin D Levels Associated with Type 2 Diabetes

The incidence of type 2 diabetes has increased substantially in both high-income and low- and middle-income countries in recent decades. Observational studies have reported that higher plasma 25-hydroxyvitamin D (25[OH]D) concentrations are associated with lower risks of diabetes, but it is unclear if these associations are causal. More...
06 Jun 2018
Image: The PATHFAST compact immunoanalyzer used for measuring cardiac troponin (Photo courtesy of Mitsubishi Chemical Europe).

Troponin Assays Evaluated for Acute MI

In hospital laboratories and in point-of-care testing, cardiac troponin measurements are achieved by various assays, including “contemporary,” “sensitive” and “highly-sensitive” assays. More...
05 Jun 2018
Image: The Luminex 200 System is a flexible analyzer based on the principles of flow cytometry (Photo courtesy of Luminex).

Method Developed to Detect AFP and GP73 Simultaneously

Liver cancer is the second leading cause of cancer death in males and the sixth in females worldwide. An estimated 782,500 new liver cancer cases and 745,500 deaths occurred worldwide during 2012. More...
05 Jun 2018
Image: The DELFIA Xpress immunoassay analyzer for prenatal screening (Photo courtesy of PerkinElmer).

Serum Biomarkers Improve Preeclampsia Screening

Preeclampsia (PE), which complicates 2% to 3% of pregnancies, is a major cause of mortality and morbidity for the mother and perinatal death and impairment for the baby. More...
31 May 2018
Image: The LTQ Orbitrap XL hybrid ion trap mass spectrometer (Photo courtesy of Thermo Fisher Scientific).

New Acquisition Method Expands MS Range and Sampling Depth

A major challenge for proteomics, particularly in studies using complex samples with high dynamic ranges, is that only a small proportion of peptides in a sample are selected for analysis. More...
31 May 2018
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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