Clinical Chemistry
Plasma Human Proteins Associated with Acute Pediatric Malaria
Severe malaria caused by Plasmodium falciparum continues to be one of the leading infectious causes of morbidity and mortality in children worldwide. The intimate interaction between the pathophysiology of the human host and the biology of the P. falciparum parasite results in a wide spectrum of disease outcomes in malaria. More...27 Nov 2018
Proteins Used for Diagnosing ALS
Proteins have been identified that may be useful in both earlier diagnosis of Amyotrophic Lateral Sclerosis (ALS) and in more accurate disease prognosis. ALS, often referred to as Lou Gehrig's disease, is a progressive, neurodegenerative disease that affects the brain and spinal cord. Currently, there is no effective treatment or cure. More...20 Nov 2018
Chromaffin Cell Tumors Diagnosed by Plasma Panel
Pheochromocytomas and paragangliomas include adrenal and extraadrenal chromaffin cell tumors as well as head and neck paragangliomas and measurements of plasma or urinary metanephrines are recommended for diagnosis of pheochromocytoma and paraganglioma (PPGL). More...19 Nov 2018
Cardiac Troponin Assays Compared in Large Cohort
High-sensitivity (hs) assays for the measurement of cardiac troponin T (cTnT) and cardiac troponin I (cTnI) are now used widely for the diagnosis of myocardial infarction. The universal definition of myocardial infarction recommends the 99th centile derived from a normal reference population be used to define myocardial necrosis. More...19 Nov 2018
Plasma Lactate Measurement Used to Test Variability
Clinical laboratories are required to adhere to manufacturers’ recommended sample handling instructions as part of their compliance with accreditation certification. However, manufacturer's recommendations do not always reflect current practice and deviations from recommendations necessitate extensive validation studies. More...05 Nov 2018
Novel POC Troponin Assay Rules Out Acute MI
More than seven billion diagnostic tests are run in the USA each year to help physicians make accurate, timely decisions about a person's medical treatment. Emergency department (ED) investigations of patients with suspected acute myocardial infarction (AMI) are time consuming, partly because of the turnaround time of laboratory tests. More...05 Nov 2018
Chronic Inflammation Linked to Risk for Alzheimer's Disease
While it has been widely shown that possessing the apolipoprotein E4 (ApoE4) gene is the major genetic risk factor of Alzheimer's disease (AD), not all ApoE4 carriers develop AD. It is likely that a complex interaction of genetic vulnerabilities with environmental risk factors lead to AD and identifying such factors could be beneficial for the prevention of AD. More...30 Oct 2018
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Blood Tests Differentiate Myocardial Injury from Infarction
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Ovarian Cancer Biomarker Predicts Therapy Response
Nano-LCMS Differentiates Liver Diseases
High-Sensitivity Cardiac Troponin I Assay Validated
Novel Biomarkers Predict CV Events in Type 2 Diabetes
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Elevated Triglycerides Associated with Risk of PAD
High Levels of Aldosterone Increase Risk of Diabetes
Blood Test Screens for Secondary Heart Attack
New Biomarker Panel Could Accelerate Autism Diagnoses
Residual Tissue Repositories Suitable for MS-Based Proteomics
Prognostic Biomarkers Identified for Aggressive Breast Cancer
Biomarker Low Predictive Power Validated for eGFR Decline
Inflammation Biomarkers Identified as Risk of Polyneuropathy
Sleep Disorder Linked with Abnormal Lipid Levels
Serum S-100β Elevated in Septic Shock Patients with Delirium
Blood Test Identifies Gestational Diabetes Risk in First Trimester
Biomarkers Explored in Patients with Acute Coronary Syndromes
The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.