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Clinical Chemistry

Image: Low serum creatinine is associated with the risk of diabetes (Photo courtesy of Jo Lewin).

Low Serum Creatinine Associated with Diabetes Risk

Creatinine is the only metabolite of creatine phosphate in the skeletal muscle and under the steady state; it is created at a relatively constant rate by the body depending on the total skeletal muscle mass. More...
02 May 2019
Image: Q-Exactive HF Hybrid Quadrupole-Orbitrap mass spectrometer coupled to a Dionex Ultimate 3000 RSLC Nano system (Photo courtesy of Thermo Fisher Scientific).

Parallel Assays Developed for CSF Alzheimer's Disease Proteins

Detailed knowledge of protein changes in cerebrospinal fluid (CSF) across healthy and diseased individuals would provide a better understanding of the onset and progression of neurodegenerative disorders. More...
29 Apr 2019
Image: Scientists examined whether timing of C-peptide responsiveness during an oral glucose tolerance test might explain variance in HbA1c levels at diagnosis of type 1 diabetes (Photo courtesy of Amit Akirov, MD).

C-Peptide Responsiveness May Explain HbA1c Variation

The addition of timing measures of C-peptide responsiveness may partly explain the glycated hemoglobin (HbA1c) level variation at diagnosis of type 1 diabetes (T1D) during the oral glucose tolerance test (OGTT). More...
24 Apr 2019
Image: The Minicare I-20 handheld diagnostics platform is designed to detect multiple target molecules at very low concentrations in a single ‘finger-prick’ blood sample, and display the results on a handheld analyzer within minutes (Photo courtesy of Philips Healthcare).

B-Type Natriuretic Peptide Sandwich Immunoassay Evaluated

The measurement of circulating natriuretic peptides (NP) is considered to be a useful marker of myocardial function, and international guidelines recommend its use for the diagnosis of patients with heart failure (HF), and in particular ruling out the presence of HF. More...
23 Apr 2019
Image: A blood test for high‐density lipoprotein that may indicate adverse renal outcomes for patients with chronic kidney disease (Photo courtesy of Drs. Wolfson).

HDL‐C Levels Associated with Harmful CKD Progression

Serum high‐density lipoprotein (HDL) has traditionally been considered to be protective against cardiovascular disease in the general population. HDL exerts an antiatherogenic effect through reverse cholesterol transport, a multiorgan process that removes excess cholesterol from lipid‐laden macrophages and peripheral tissue. More...
17 Apr 2019
Image: The Automatic QC RAPID Systems RAPIDPoint 500 blood gas analyzer (Photo courtesy of Siemens Healthcare).

Capillary and Venous Lactate Compared in ED Patients

Elevated lactate levels are a common finding in acutely unwell patients. Blood lactate level is a good predictor of patient outcome and high lactate levels are associated with high morbidity and mortality. Lactate may be detected and measured in all blood samples: arterial, venous and capillary. More...
16 Apr 2019
Image: The AfinionHbA1c assay cartridge is used to test for quantitative determination of glycated hemoglobin (HbA1c) in human whole blood, which is used to monitor metabolic control in patients with diabetes (Photo courtesy of Alere).

HbA1c Point-of-Care Test Reliably Diagnoses Diabetes

Glycated hemoglobin is a form of hemoglobin that is covalently bound to glucose. It is formed in a non-enzymatic glycation pathway by hemoglobin's exposure to plasma glucose. More...
11 Apr 2019
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.