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Clinical Chemistry

Image: A major new study on the association between blood glucose levels, including HbA1c, and risks of organ impairment in people with type 1 diabetes can make a vital contribution to diabetes care (Photo courtesy of HealthEngine).

Blood Sugar Levels Affect Risks in Type 1 Diabetes

Type 1 diabetes is the predominant form of diabetes diagnosed in childhood and is characterized by increased blood glucose levels resulting from insulin deficiency. More...
11 Sep 2019
Image: Preeclampsia is a condition that occurs only during pregnancy and some symptoms may include high blood pressure and protein in the urine. A specific phenotype narrows the risk of preeclampsia (Photo courtesy of the American Pregnancy Association).

Specific Phenotype Narrows Risk of Preeclampsia

Preeclampsia can lead to a baby being born early and can put the mother at risk of a seizure or stroke during delivery. It can also lead to damage in the kidneys, liver, lungs, heart or eyes and can increase a patient's risk for cardiovascular disease in the future. More...
10 Sep 2019
Image: The Elecsys Troponin T Gen 5 STAT assay (Photo courtesy of Roche Diagnostics).

Analytical Performance Evaluated for Troponin T Gen 5 Assay

Increased blood concentrations of cardiac troponin (cTn) I and T are indicative of myocardial injury and are the preferred biomarkers for diagnosing acute myocardial infarction (AMI). The diagnosis of AMI requires a rise and/or fall in serial cTn measurements, in addition to other clinical features. More...
05 Sep 2019
Image: The cobas e 411 analyzer is a fully automated analyzer that uses a patented Electrochemiluminescence technology for immunoassay analysis (Photo courtesy of Roche Diagnostics).

Persistent C-Peptide Secretion in Type 1 Diabetes Genetic-Related

Studies using sensitive assays for C-peptide have shown that some degree of residual insulin secretion commonly persists for more than five years after diagnosis of type 1 diabetes. There is variation in C-peptide persistence, the determinants of which are poorly understood but may be partly genetically determined. More...
04 Sep 2019
Image: A photomicrograph showing numerous completely sclerotic glomeruli and severe chronic tubulointerstitial nephritis from a patient with end-stage kidney disease (Photo courtesy of Dr. Jian-Hua Qiao, MD, FCAP).

Proteinuria Contributes to Greater CKD Progression Risk in Men

Older men with chronic kidney disease had a 50% increased risk for progression to end-stage kidney disease (ESKD) compared with women and this may be the result of higher levels of proteinuria. More...
29 Aug 2019
Image: The BC-5800 hematology autoanalyzer (Photo courtesy of Mindray).

Platelet Volume Related to Geriatric Patient In-Hospital Mortality

Treatment of acute coronary syndrome involves inhibition of platelet activity and thrombus formation. Platelets play a significant part during myocardial infarction by enhancing microvascular obstruction and secreting vasoactive peptides. More...
28 Aug 2019
Image: The cobas b 101 POC system; an in vitro diagnostic (IVD) test system offering C-reactive protein, HbA1c and a complete lipid profile (CHOL, HDL, LDL, TG) on one device at the point of care (Photo courtesy of Roche Diagnostics).

C-Reactive Protein Point-Of-Care Test Evaluated

C-reactive protein (CRP) is a key mediator of the acute-phase response, with blood levels of CRP increasing rapidly after an inflammatory stimulus. Therefore, changes in serum levels of CRP are a clinically useful marker of infection, inflammation, and tissue injury. More...
27 Aug 2019
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.